Notices tagged with repositioning
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Drug Repositioning: An Effective Approach in Drug Development
High cost and low pace of traditional drug discovery and development process have shifted the interest of major pharma companies towards finding new use of already existing drugs. Drug-repositioning is creating a buzz specially in rare and neglected diseases as it decreases the overall cost of bring a drug to the market. Repurposing is based on observations, existing disease information, pathways, targets, ligands, drugs pleiotropic effect. Utilization of already existing drugs for new diseases is cost effective and time saving since pharmacology, safety, toxicity, and formulation profiles of these drugs are already established. Benefits of Drug-Repositioning The drug-repositioning is an important lever for pharma companies to improve R&D productivity and enables R&D teams to: • Fast-track development and reduces risk - Repositioning can reduce drug development process from the typical 10-17 years for a de novo drug to 3-12 years (Exhibit 1). Further, this lowers risk because the molecule’s pharmacokinetic and safety profile are already known. • Increase revenue and return-on-investment - Repositioning can characterize more profitable indications and recover abandoned projects. • Expand IP Protection- New uses for an existing molecule can result in extended patent protection, depending on the level of novelty and whether any reformulation is involved. Further, proactively recognizing indication expansion opportunities earlier in development process can result in achieving greater revenue during the period of exclusivity For the complete informative article on the ‘Drug Repositioning’, please visit @ https://www.iebrain.com/drug-repositioning-an-effective-approach-in-drug-development/ About Ingenious e-Brain Solutions: - Ingenious e-Brain Solutions provides high-quality, customized, and cost-effective Technology Intelligence, Business Intelligence, and Intellectual Property Intelligence solutions to industry leaders, and innovative companies across the globe. Innovation, knowledge, and transparency form the basis of our company’s mission and vision. Along with cost benefits, we provide highest quality results ensuring fool-proof confidentiality and security. We are an ISO certified company with offices in India and USA. Ingenious e-Brain Solutions has a strong team of analysts, and subject matter experts with domain proficiency which is devoted to help clients grow. Our highly qualified professionals offer tailored, value-added and cost-effective services to our clients. We believe in building long term relationships with our clients who include national and international corporations, Fortune 500 companies, world’s leading research institutes and universities as well as independent inventors. Get in Touch: - India Office 207-208 Welldone TechPark, Sohna Road Sector 48, Gurugram, Haryana 122018, India +91 124 429 4218 Email: - queries@iebrain.com
about 3 months ago from web -
Cosmetic Bonding Dentist in The Colony
The #1 Dentist in Castle Hills of Lewisville, The Colony, Frisco, & Carrollton, TX. We know that anxiety and dread are the most common issues for all patients. Every day, we work hard to reduce any discomfort or agony and provide compassionate dental care for the entire family. At our dental office in Castle Hills, Dr. Daniel and his staff are passionate about dentistry and genuinely concerned about patients' teeth and gums. The process of getting the ideal smile you've always wanted starts with us educating you on the process and outlining how you can reach your long-term objectives. Contact our cosmetic dentist in The Colony today.
about 5 months ago from web -
How Dental Crowns and Bridges Change Your Smile?
Dental crowns and bridges are common processes performed by specialist dentists. Their general role is restoring the tooth or teeth to their chewing function. Crowns and bridges are of several types, and since bridges consist of crowns, let us tell you all about both crowns and bridges.
about 5 months ago from web -
Why Sedation Dentistry May Be the Best Option for You?
Sedation dentistry may be able to help you if you suffer from dental anxiety. Everything, from routine dental cleanings to more invasive operations, can be done under sedation.
about 7 months ago from web -
TOP DENTIST IN CASTLE HILLS OF LEWISVILLE
NICE TO MEET YOU At D. Dental, we understand that the two most important concerns for all patients are cost and pain anxiety. As a result, we strive every day to minimize pain while providing gentle dental care that is affordable for the entire family. We know that anxiety and dread are the most common problems for all patients. Every day, we strive to relieve any pain or anguish while also providing compassionate dental care for the entire family.
about 8 months ago from web -
How Long Do Dental Crown and Bridges Last?
Dental crowns and bridges are typically used to protect and support teeth that have become weak over time as a result of extensive damage and decay.
about 8 months ago from web -
DENTISTS IN THE COLONY
D. Dental is committed to giving patients the most beautiful, healthy, and natural-looking smiles possible. We know that anxiety and dread are the most common problems for all patients. Dr. Ryan Daniel takes pride in his attention to detail and the use of cutting-edge procedures and technologies to ensure a painless and comfortable experience.
about 8 months ago from web -
Finding the Right Solution for Your Gummy Smile
A gummy smile is a common dental cosmetic issue. Fortunately, there are many cosmetic dentistry treatments that make it possible to change the amount of gum tissue surrounding your teeth, allowing you to have a more natural and pleasing smile.
about a year ago from web -
BEST COSMETIC DENTIST IN DALLAS
Our goal at D. Dental is to provide the greatest quality regular, hygiene, and cosmetic dental services. We utilise and supply cutting-edge technical advances to give our patients with unsurpassed care. D. Dental, with the most advanced dental equipment and facilities, provides a wide range of general and cosmetic dental services to help you achieve a beautiful and satisfying smile.
about a year ago from web -
Dental Implant Procedures Making Your Smile Great Again
Are you ashamed to smile because you have missing teeth? Do you find yourself covering your mouth when talking? It is understandable why some people would feel this way. If you feel ashamed, self-conscious or unattractive because of your teeth, do not lose hope just yet.
about a year ago from web -
What are the Signs or Symptoms that I Need a Dental Filling?
Dental fillings help restore cavities and dental problems that would have caused a huge problem in your dental health. Basically, they are used to plug up holes in the teeth left by tooth decay so teeth can continue functioning and remain healthy.
about a year ago from web -
How Often Do You Need Scaling and Root Planing?
Do you have red, tender, and bleeding gums? You might have an accumulation of plaque at the gumline. Plaque contains harmful bacteria that attach to the healthy tissue around the gums and teeth.
about a year ago from web -
Are You Thinking About Getting Porcelain Veneers? Here’s What You Should Know
For many people, having less than perfect teeth can make them self-conscious. And although it is important to feel good about yourself no matter what, it is understandable that unattractive teeth can affect your confidence.
about a year ago from web
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